Egg's way to segregate chromosomes
Nick Chun So
During meiosis, the egg (in cyan) halves its set of chromosomes (in grey) before fertilization. Since the first ultrastructural study dated back to the 50s, how the egg assembles the specialized spindle apparatus (in magenta) differently from normal body cells was poorly understood. In a recent study, we discovered the liquid-like spindle domain (in green), a membraneless compartment of microtubule regualtory factors, which is essential for spindle assembly and faithful chromosome segregation in mammalian eggs.